4T1 is a mouse breast cancer cell line (of stage IV human equivalent) and is a 6-thioguanine resistant cell line selected from the 410.4 tumor without mutagen treatment. It is a highly tumorigenic model …

Another advantage of 4T1 is its resistance to 6-thioguanine. This property enables precise quantitation of metastatic cells, even when they are disseminated and at sub-microscopic levels in distant organs, …

In this model, 4T1 cells are typically implanted either orthotopically or subcutaneously in BALB/c mice, and the resulting tumors closely mimic the metastatic behavior seen in human breast cancer.

Mar 29, 2019 · In order to develop a mouse model to investigate the fate of DTCs, we utilized two murine tumors: 4T1, an extremely metastatic in syngeneic BALB/c model 24 representing the triple …

The tumor growth and metastatic spread of 4T1 cells in BALB/c mice very closely mimic human breast cancer. This tumor is an animal model for stage IV human breast cancer.

The 4T1 tumor model utilizes the 4T1 cell line, due to its ability to closely mimic the tumor microenvironment and the behavior of triple-negative breast cancer (TNBC), the 4T1 tumor model is …

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The mouse 4T1 breast cancer model is used to study antitumor immunity, combination therapies with cisplatin, and tumor cell death, offering a comprehensive view of breast cancer treatment efficacy.

It is one of four sublines derived from the 410.4 tumor, which was isolated from a single spontaneously arising mammary tumor of a MMTV+ BALB/c mouse foster nursed on a C3H mother (BALB/BfC3H;...

The 4T1 cell line was derived from a spontaneous mammary tumor in a mouse and is often used to study the metastatic spread of breast cancer to other parts of the body, as well as potential …